Rivastigmine and aqueous extract of Olibanum may boost the expression of FMR1 gene in AlCl3-induced Alzheimer’s disease model rats

Alzheimer s disease (AD) is a multifactorial disorder that it´s progression is associated with many genetic and environmental factors. Many studies showed that FMR1 gene is important in AD because FMR1 protein is participated in regulating of APP production. So, we investigated the effects of aqueous extract of Olibanum and Rivastigmin on the expression of FMR1 gene in AlCl3-induced Alzheimer’s disease model rats. 28 adult male rats were treated with AlCl3 (20 mg / kg) for 60 days and then randomly divided into 4 groups (n=7). Group 1 was treated with Rivastigmine(0.3 mg / kg), group 2 with aqueous extract of Olibanum(200 mg / kg) group 3 with AlCl3 (20 mg / kg) and group 4 with distilled water (1 ml) for 60 days. Animals were tested with Morris-Water-Maze and their hippocampus was isolated and used for FMR1 gene expression analysis by real-time PCR. Morris-Water-Maze test showed that AlCl3 impairs memory performance in rats, while treatment with Rivastigmine or aqueous extract of Olibanum improves learning in the AlCl3-treated rats. Moreover, real-time PCR data analysis indicated that while AlCl3 led to significant reduction in FMR1 gene expression, Rivastigmine and aqueous extract of Olibanum increased its expression.

کلیدواژه ها:

Rivastigmin ، Olibanum ، FMR1 ، Alzheimers’s disease