Study of miR-335 and GBP2 gene expression levels in ductal carcinoma breast cancer as possible candidate cancer biomarker

Introduction: Breast cancer is the most common cancer among women in the world, but its diagnosis in the early stages increases the chance of recovery and survival of the patient. GBP2 is a member of GBP family. GBP2 has been discussed as a possible control factor in tumor development in breast cancer that have potential to be a tumor marker.Materials and Methods: In this project, the Real-Time RT-PCR technique was used to analyze expression of mir-335 and GBP2 gene as its target in tumor and normal adjacent breast tissue of 35 patients with ductal carcinoma breast cancer compared with normal adjacent breast tissues.Results: Our results indicated that The GBP2 gene and miR-335 was down regulated in tumor tissues compared with normal adjacent breast tissues.Conclusions: As a consequence, GBP2 expression are associated with breast cancer as possible biomarker.

کلیدواژه ها:

Breast Cancer ، Gene Expression ، miR-335 ، Real Time PCR ، GBP2 ، microRNA ، Biomarker