Hereditary Hearing Loss and Consanguinity in Turkmen Population of Iran: A Retrospective Study
محل انتشار: مجله بین المللی کودکان، دوره: 7، شماره: 11
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 415
فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_INJPM-7-11_002
تاریخ نمایه سازی: 17 دی 1398
چکیده مقاله:
Background: Our research focuses on different dimensions of families of Turkmen population of Iran with two or more than two affected members. A complete clinical ear test was conducted on them. It was aimed to find families with the highest chance of hereditary hearing impairment among siblings and also existence of consanguinity among their parents. Materials and Methods All Turkmen families with at least two hearing impaired members were screened based on prenatal and postnatal histories, family medical history, socioeconomic status as well as physical examination. For confirmation of hereditary hearing loss, a comprehensive evaluation including prenatal, perinatal and postnatal history, family medical history, pattern of inheritance, consanguinity, and three generation pedigree, the physical examination, and genetic screening by a genetic expert were used. They were referred for complete hearing evaluation including pure tone audiometry, speech recognition threshold, otoacoustic emission and auditory brainstem response. Results A total of 82 families with 198 hearing impaired patients were diagnosed with about 60% having two and the rest with more than two affected members. Nearly 89% (n=175) of the patients had the inherited type of hearing loss among which 95% (n=167) demonstrated non-syndromic symptoms. The rate of consanguinity among parents of the patients was about 65%. Conclusion This research revealed a high incidence of hereditary hearing impairment and consanguinity among Turkmen population which is in agreement with other reports from Iranian population with deaf children. In general, the rate of consanguinity in Iranian population is 38%. Therefore, it seems that consanguinity is higher in families with hearing-impaired children.
کلیدواژه ها:
نویسندگان
Maryam Hajilari
Department of Medical Genetics, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Morteza Oladnabi
Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran AND Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Anvarsadat Kianmehr
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Mohammad Hossein Taziki
Department of Otorhinolaryngology, Golestan University of Medical Sciences, Gorgan, Iran.