Therapeutic Effects of Nano-Phytosome of Quercetin on Inflammatory Responses in a Chronic Mouse Model of Multiple Sclerosis

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 507

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شناسه ملی سند علمی:

NSCMED08_408

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Patients with multiple sclerosis (MS) have higher levels of inflammation and anti-inflammatory agents can be used for treatment of MS. The natural agents are safe but have limitations and need a novel formulation. This study was conducted to evaluate therapeutic effects of nano-phytosome of Quercetin on inflammatory responses in a chronic mouse model of MS.Methods : Phytosomes were fabricated through thin layer hydration procedure and their particle size, and encapsulation efficiency (EE) were assessed. A total number of 60 mice were divided into 5 groups, including Control, 150 Q, 300 Q, 150 NQ and 300 NQ that were treated with PBS, 150 mg/kg Quercetin, 300 mg/kg Quercetin, 150 mg/kg nano-phytosome and 300 mg/kg nano-phytosome of Quercetin. At the end of the trial, the serum concentrations of granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-17 (IL-17), interferon gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) were assessed.Results : The results showed that oral administration of Quercetin and nano-phytsome of Quercetin significantly decreased the serum concentrations of GM-CSF, IL-1 , IL-2, IL-6, IL-17, IFN- and TNF- and increased the levels of IL-10 compared to the control group (P<0.05), but animals treated with nano-phytsome of Quercetin significantly decreased GM-CSF, IL-1 , IL-2, IL-6, IL-17, IFN- and TNF- and increased the levels of IL-10 compared to Quercetin group (P<0.05).Conclusion : The use of nano-phytosome of Quercetin could efficiently improves inflammation. We recommend the use of nano-phytosome of Quercetin for alleviating inflammation in patients with MS.

نویسندگان

Parnia Tarahomi

Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran

Seyed Ali Seyedinia

Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran

Majid Askaripour

Department of Physiology, School of Medicine, Bam University of Medical Sciences, Bam, Iran

Faezeh Nemati Karimooy

Department of Neuroscience, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran

Golareh Mohaghegh Daghigh

Georgian Center for Neuroscience Research, International Center for Intelligent Research, Tbilisi, Georgia

Nasroallah Moradi-Kor

Georgian Center for Neuroscience Research, International Center for Intelligent Research, Tbilisi, Georgia