The effects of Olibanum on memory impairment induced by Scopolamine in rats

Background and Aim : Olibanum as a resin of Boswellia serrata (B. serrata) from Burseracea family has been proposed as an effective anti-inflammatory and antioxidant agent. We are suggested that this resin can attenuate the generation of oxidant agents and reinforce the anti-oxidant agents to improve memory impairment induced by scopolamine.Methods : Forty male Wistar rats were divided into four groups (n=10 each group): Control (diluted DMSO + saline), Scopolamine (diluted DMSO + 1mg/kg Scopolamine), Scopolamine- Oliban 100 and Scopolamine- Oliban 200 (Olibanum 100 mg/kg or 200 mg/ kg before Scopolamine). Learning and memory performance and biochemistry data were evaluated in all groups.Results : Scopolamine administration increased the duration and distance to find the platform in the Morris water maze(MWM) test in compare to control group in 5 days (P<0.05 to P<0.001) while, scopolamine decreesed the latency to enter to the dark compartment after receiving the sock in passive avoidance (PA) test (P<0.001). Pretreatment with both doses of Olibanum enhanced performances of the rats in MWM (P<0.05 to P<0.01) and PA test (P<0.01 to P<0.001). scopolamine also increased hippocampal MDA levels (P<0.001) while, decreased CAT, SOD and thiol (P<0.001). Olibanum increased hippocampal CAT, SOD and thiols (P<0.01 to P<0.001).Conclusion : Olibanum showed an anti-inflammatory and antioxidant properties. It could improve memory impairment induced by scopolamine.

کلیدواژه ها:

Boswellia serrate ، Olibanum ، Memory impairment ، oxidative stress