Activation and recruitment of the endogenous neural stem cells for management of the multiple sclerosis. A view point in the field of regenerative medicine

Background and Aim : Multiple sclerosis (MS) as a persistent neuroinflammatory disturbance of the central nervous system which leads to severe neuropathological altrations and irreversible functional deficits. Neurodegeneration results from the devastation of myelin sheaths and following axonal demyelination which is mediated by the immune system reaction including T lymphocytes autoreactivation. Common MS therapies, including immune system agents, are designed to reduce the recurrence of the disease. However, these factors are usually not sufficient to treat throghly chronic neurological disability. A promising prospect for future therapeutic of MS is replacing damaged oligodendrocytes and neurons. Importantly, activation and recruitment of resident oligodendroglial precursor cells oligodendrocytes can generate new myelin sheaths partly. However, this recovery process is limited and fails with the progress of MS, much concern has advanced consideration the progress of remyelination-promoting tactics and the existence of other cell types, which can also provide the amendment of myelin sheaths. There is a minimum of two neurogenic niches in the adult brain which has long-lived adult neural stem cells (NSCs). Many studies have begun to elucidate NSCs in pathological conditions and have revealed their potential in myelin repair activity. Here we ll discuss the role of neural stem cells in the repair of MS lesions and underlying mechanisms.Methods : here we review the papers about neural stem cell and multiple sclerosisResults : Here we ll discuss the role of neural stem cells in the repair of MS lesions and underlying mechanismsConclusion : Here we ll discuss the role of neural stem cells in the repair of MS lesions and underlying mechanisms.

کلیدواژه ها:

neural stem cell ، multiple sclerosis ، treatment