The protective role of gallic acid nano phytosome on recognition memory impairment in prenatal valproic acid-induced rat model of autism

Background and Aim : Autism Spectrum Disorders (ASDs) is a neurodevelopmental disorder characterized by impairments in social interaction and communication and cognitive deficits. Phytoconstituents like gallic acid are poorly absorbed due to their multiple ring large size molecules and their poor availability. In this study, we investigate the neuroprotective effects of gallic acid nano phytosome on recognition memory impairment prenatal valproic acid-induced rat model of autism.Methods : . rat model of autism was induced by a single intraperitoneal injection of 500 mg/kg sodium valproic acid to female rats at gestational day (E12.5) peritoneally. Male offspring in the control group received distilled water. VPA-induced male offspring were divided into three groups: VPA group, VPA treated with gallic acid (GA) and gallic acid nano phytosome (GNP) groups at doses of 20 mg/kg from PND 21 until PND 51. Novel object test was conducted on postnatal day 50-51.Results : Based on our results, a rat model of autism exhibited recognition memory impairment (P<0.001). GA and GNP were significantly reversed recognition memory impairment compared to the autistic rat (P<0.001).Conclusion : These findings indicated that administration of gallic acid nano phytosome more ameliorates VPA-induced learning and memory deficits than gallic acid may be through enhancing the oral bioavailability.

کلیدواژه ها:

Autism ، Gallic acid nano phytosome ، memory impairment ، rat