ALTERATION OF BDNF AND 5HTTPLR GENES MRNA LEVEL IN OPIUM ABUSERS AFTER TAPER OFF TREATMENT

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 449

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شناسه ملی سند علمی:

KAMED13_035

تاریخ نمایه سازی: 10 دی 1398

چکیده مقاله:

Background and Aim : Opium is the dried latex obtained from the opium poppy. Opium addiction is the most prevalent addiction in Iranian society. During last two decades congress 60 a nongovernmental organization, have been performed a taper off treatment of opium associated with a package of psychological treatments group classes. While the effectiveness of taper off method in opium addiction has been confirmed, molecular mechanisms of this treatment in addicts are not totally clarified. BDNF gene is a brain derived neurotrophic factor which is related to several molecular mechanisms of brain including memory. 5HTTPLR is a transporter of serotonin that is related in decision making process. Methods : In present study mRNA level of BDNF and 5HTTPLR genes in peripheral blood of 20 non-psychiatric persons and 79 opium addicted individuals before and after six months period of taper off treatment examined by using Real Time PCR. Also executive functions including memory and decision making were analyzed in all participants.Results : Results showed significant down expression of BDNF and 5HTTPLR in addict persons vs. non-psychiatric persons. Also significantly increase detected in BDNF (p<0.01) and 5HTTPLR (p<0.01) expression level in addicts after six months of therapy period. Also significant improvement of memory and decision making were revealed in addicts after therapy and these improvements were correlated with expression level of BDNF and 5HTTPLR. Conclusion : Findings revealed effect of opium abuse and taper off treatment on expression of BDNF and 5HTTPLR. Also association of BDNF mRNA level with psychological states of addict s individuals detected. Results of present study may help to better understanding from molecular and neurological mechanisms of opium and taper off treatment. Also present BDNF and 5HTTPLR as potential markers for screening the effectiveness of different kinds of addiction treatment.

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نویسندگان

Ani Dezhakam

Department of biology, science and research branch,Islamic Azad university, Tehran, Iran

Arvin Haghighatfard

Department of genetics, Tehran Medical sciences branch,Islamic Azad university, Tehran, Iran

Peyman Hassani Abharian

Department of neuroscience, Institute for Cognitive Science Studies, Tehran, Iran

Azade Hekmat

Department of biology, science and research branch,Islamic Azad university, Tehran, Iran