Efficacy and safety of amikacin in the prevention of postoperative infection following general surgery: A systematic review and meta-analysis

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 347

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شناسه ملی سند علمی:

ARCIORSMED02_175

تاریخ نمایه سازی: 4 دی 1398

چکیده مقاله:

Background: Surgical site infections (SSIs) are the leading cause of hospital-acquired infections. Antibiotic prophylaxis plays a major role in preventing of SSIs. Amikacin is an antibiotic used for a number of bacterial infections such as joint infections, intra-abdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. In some studies, amikacin can perform as a prophylactic antibiotic but this effect is not cleared. This meta-analysis reviews all study about the effect of amikacin in the prevention of postoperative infection.Methods: The relevant empirical literature was identified by searching several electronic databases: PubMed and NLM Gateway (for MEDLINE), Institute of Scientific Information (ISI), SCOPUS and EMBASE, from 1 January 1991 to 31 May 2019. The search was performed by cross-referencing the words amikacin and surgical site infection or etc. The search strategy was inspired by the approach from the PRISMA guideline for systematic reviews. The analyses were conducted with SPSS software, version 23.0.Results: The reported prevalence is presented as percent and 95% confidence interval. The search yielded 73 publications that were related to inclusion criteria. According to titles, 50 publications were excluded as clearly ineligible, leaving 23 for further review. Of these 23 studies, 21 had been reported that amikacin had a significant beneficial effect in the prevention of SSIs following surgical procedures such as neurosurgery, colorectal surgery, and hip arthroplasty but it could cause hearing loss and some kidney problems. Additionally, the effect of amikacin was more than cefazolin and gentamicin in the same dose. Finally, amikacin use in surgical patients was supported in hospital environments where gentamicin resistance is judged to be a significant clinical risk factor.Conclusion: Current evidence indicates that infection rates after general surgery are reduced considerably by antimicrobial prophylaxis by amikacin. The results of the current study indicated that amikacin effectively protects patients against SSIs.

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نویسندگان

Hossein yusefi

Student research committee, Qom University of Medical Sciences, Qom, Iran

Seyed Ahmad Bathaei

Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran