Synthesis of Nano cluster {Mo132} - polyacrylonitrile nanofibers for the extraction of methadone in human urine sample

Polyacrylonitrile/{Mo132} composite nanofibers mats was synthesized by an electrospinning technique using PAN and giant ball nano-polyoxomolybdate {Mo132}. {Mo132} [1] was mixed with PAN solution and then electrospun to produce bead-free nanofibers. The aim of this study is to evaluate the extraction abilitiy of electrospun composite nanofibers against methadone.In many countries of the world, the selected treatment for opiates dependence is methadone maintenance therapy (MMT). Methadone (Fig. 1), also known as Methadose, Dolophine, Amidone, Symoron, Physeptone, Heptadon and many other names, is a synthetic analgesic drug which is commonly used to treat dependence on heroin and other opioids since the mid-1960s. Because methadone treatment replaces a short-acting opioid (heroin) with a long-acting opioid (methadone), it has been controversial since its inception, particularly with regard to adequate dose levels [2]. The surface morphology and other properties of the PAN/{Mo132} nanofibers composite were characterized by various techniques, including SEM, TEM, FT-IR, UV-Vis. SEM images showed that the average diameter of the fibers was between 100-120 nm. [3]