A(1) Milk and Beta-casomorphin-7

Milk is composed of water, proteins, lipids, lactose, vitamins and minerals; each performs different technological and physiological functions. More than 80% of most mammal’s milk proteins are constituted by caseins. Casein is a group of proteins and they are sub-divided into αs1-, αs2, β- and k-casein families. Among these casein families, -casein is the second most abundant protein. Different mutations in the cow milk beta casein gene led to 12 genetic variants (A1, A2, A3, B, C, D, E, F, G, H1, H2 and I) and most common of these are genetic variants A1 and A2. The A1 and A2 variants differ only at amino acid position 67, which is histigine in A1 or proline in A2 milk. This difference in amino acid sequence suggests a conformational change in the secondary structure of the expressed β-casein. Milk that contains A1 β-Casein and A2 β-Casein are known as A1 milk and A2 milk, respectively. A1 β-Casein is commonly found in milk from crossbred and European breeds of cattle. A2 β-Casein is found mostly in milk from indigenous cows and buffaloes of India and Asia. A1 β-casein milk releases an amino acid bioactive peptide called beta-casomorphin-7 (BCM-7) in small intestine. Production of BCM-7 from A1 milk consumption is four fold higher in infants compared to aduts. Betacasomorphin-7 released from A1 β-casein is responsible for many human disorders like Type 1 diabetes, autism. Schizophrenia, Alzheimer’s disease (AD), Attention deficit hyperactivity disorder (ADHD), Multiple sclerosis and heart diseases. The A1 milk’s calcium to magnesium ratio is 10:1 while the ideal ratio (A2 milk’s) i.e., 2:1. Therefore consumption A1 milk lead to magnesium deficiency and Ca: Mg imbalance. A1 Milk may also cause acne, eczema, upper respiratory infection, asthma, ear infections, tonsillitis and allergies. The inflammation from A1 milk casein causes lymphatic congestion and metabolic suppression. But A2 milk does not cause such type of illnesses and disorders.

کلیدواژه ها:

A1 milk ، A2 milk ، Beta-casomorphin-7 ، β-Casein