Evolution of the antibiotic-resistance of microorganisms causing nosocomial infections: A 2-year epidemiological surveillance study in a hospital population

Background: Hospital infections and antibiotic resistance are numerous issues that have been reported worldwide over the years and lead to costly and long-term treatment.Multidrug-resistant patterns in bacterial pathogens have resulted in difficult-to-treat infections with conventional antimicrobials and this is a worldwide challenge associated with high morbidity and mortality. In this study, we describe the antibiotic-sensitivity profile of Nosocomial infections in hospitalized patients and discusses the impact of this as a persistent, global health threat. Methods: In this cross-sectional study, we assessed the results of cultures and antibiograms from urine, wound, and blood samples from all patients with NIs who have admitted to BO-ALI SINA hospital, with a microbiological confirmation of nosocomial infection between March 2016 to March 2018. SPSS 16.0 was used for statistical calculations. Results: During the 2 years of the study, During the 2 years of the study, the most common isolated microorganisms in all infectious cultures were Escherichia coli (48.8%), Staphylococcus epidermidis (22.9%) and Klebsiella Pneumoniae (12%) in both sexes. E. coli had the highest resistance rate to ampicillin (88.7%) and cefalexin (74.2%). S. epidermidis, K. pneumonia and had the highest antibiotic resistance rate to ampicillin (90.5%, 92.7% respectively). E. coli showed the highest sensitivity to vancomycin (95.5%) and gentamycin (73.3%). S. epidermidis was more sensitive to amikacin (93.5%) and vancomycin (89.5%). Conclusion: Given the increasing, the rate of antibiotic resistance in this region, Political agendas, development of therapies, surveillance of practice, new treatments, make a precise reporting and improve the procedures of infection control in hospitals are necessary to the decreasing this rate. Finding strategies against the development of antibiotic resistance due to the current shortage of effective therapies, lack of successful prevention measures, and lack of new antibiotics is a major global challenge for the life sciences community and for public health.

کلیدواژه ها:

Nosocomial Infection ، antibiotic resistance ، hospital