The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled trial
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 506
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شناسه ملی سند علمی:
SRMMED22_001
تاریخ نمایه سازی: 19 آبان 1398
چکیده مقاله:
Background and Objective: This study was conducted to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in subjects with Parkinson s disease (PD). Materials and Methods: This randomized, double-blind, placebo-controlled clinical trial, registered in the Iranian website of registration (http://www.irct.ir: IRCT2017061234497N1) was performed in 40 subjects with PD. Participants were randomly allocated into two groups to take either 1000 mg/day of omega-3 fatty acids from flaxseed oil plus 400 IU/day of vitamin E supplements or placebo (n = 20 each group) for 12 weeks. Gene expression related to inflammation, insulin and lipid were quantified in peripheral blood mononuclear cells (PBMC) of PD patients with RT-PCR method. Findings: After the 12-week intervention, compared with the placebo, omega-3 fatty acids and vitamin E co supplementation down regulated gene expression of tumor necrosis factor alpha (TNF-α) (P = 0.002) in PBMC of subjects with PD. In addition, omega-3 fatty acids and vitamin E co-supplementation up regulated peroxisome proliferator-activated receptor gamma (PPAR-γ) (P = 0.03), and down regulated oxidized low-density lipoprotein receptor (LDLR) (P = 0.002) in PBMC of subjects with PD compared with the placebo. We did not observe any significant effect of omega-3 fatty acids and vitamin E co-supplementation on gene expression of interleukin- 1 (IL-1) and IL-8 in PBMC of patients with PD.Conclusions: Overall, omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PD patients significantly improved gene expression of TNF-α, PPAR-γ and LDLR, but did not affect IL-1 and IL-8.
کلیدواژه ها:
نویسندگان
Omid Reza Tamtaji
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran
Mohsen Taghizadeh
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran
Ehsan Dadgostar
Halal Research Center of IRI, FDA, Tehran, Islamic Republic of Iran
Reza Daneshvar Kakhaki
Department of Neurology, School of Medicine, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran