A novel one step synthesis of tragacanth coated SiO2@Fe3O4 magnetic nanoparticles and their use for drug delivery applications

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 386

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تاریخ نمایه سازی: 19 آبان 1398

چکیده مقاله:

Gum tragacanth is a viscous, odorless, tasteless, water-soluble mixture of polysaccharides obtained from sap that is drained from the root of the plant and dried[1]. In this work a novel method for one step synthesis of magnetic SiO2@Fe3O4 nanoparticles coated with tragacanth has been developed. The core–shell Fe3O4@SiO2 nanocomposites were prepared using a modified method from Stöber et al. [2]. The tragacanth coating was obtained by performing the co-precipitation of Fe2+ and Fe3+ with ammonium hydroxide and silica in a solution of tragacanth. The obtained tragacanth coated SiO2@Fe3O4 particles were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and Fourier transform infrared spectroscopy (FT-IR). The nanomagnetic particles were functionalized by ammonium hydroxide. The functionalized nanoparticles were loaded with a drug (metformin) and the drug release was investigated spectrophotometrically at physiological pH (7). The functionalized tragacanth coated displayed good adsorption and in-vitro drug release in phosphate buffer saline (pH=5). The tragacanth loaded magnetic nanoparticles were succesfuly synthesized and the results indicate that they can be used in separation and drug delivery applications.


Fereshte Farajian,

Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran

Payman Hashemi

Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran