The Effect of CD39 Expression on Multiple Sclerosis Recurrence: Systematic Review

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 305

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شناسه ملی سند علمی:

NIMED03_319

تاریخ نمایه سازی: 7 آبان 1398

چکیده مقاله:

multiple sclerosis is an autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. This disorder can have a recurrence period. Cd39 is an acidic glycoprotein and ectonucleotidase found on the surface of activated lymphocytes of all classes, endothelium, and various accessory cells within tissues. Recurrence is the return of a sign, symptom, ordisease after a remission. We searched PubMed, Google Scholar and SID search engine with acute key words multiple sclerosis , cd39 gene and recurrence . As a result of our research, 43 articles were found respectively. All articles were published between 2010 until 2019 and have ethical considerations. All the studies, use human samples. After investigating their titles 22 articles were excluded and by readingabstracts 15 articles excluded. Finally 6 articles was included. Two articles of these studies revealed that, there was a positive association between recurrence of multiple sclerosis and CD39expression. The result of on study showed the CD39 expression in RRMS wassignificantly decreased. But the other study shows that, the CD39 expression level in RRMS patients hasn’t significant difference with other MS patients. Another article results indicates, mRNA level was 70% higher in RRMS patients than other MS patients (p=0.0002).But the last article results shows that CD39 expression can inactivate extracellular ATP (as a natural exhibitor multiple proinflammatory factor) and reduces the inflammation effects. Conclusion: Until now the number of studies was done in this field was low. Wecan get more reliable results, if more studies tend to this field. As a result we think CD39 expression increase in RRMS patients to decrease extracellular ATP and decreasing proinflammatory effects.

نویسندگان

Valareza Alizadeh

Mashhad Branch, Islamic Azad University, Mashhad, Iran

Mohammadreza Khojasteh

Mashhad Branch, Islamic Azad University, Mashhad, Iran

Mohammadreza Taheri

Student Research Committee, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Parsa Shoqi

Student Research Committee, Mashhad Branch, Islamic Azad University, Mashhad, Iran