The Use of Ferrule Magnets Nanoparticles with A Polymeric PLA Polymer Coating for Temozolamide to Treat Brain Tumors

Today, an attempt is made to treat brain tumor (glioblastoma), one of the most common primary malignant tumors of the central nervous system. Although therapeutic options, such as chemotherapy, have progressed greatly, but because of the presence of a blood-brain barrier that reduces the effectiveness of the drug It turns out. Now using nanotechnology and drug loading, it’s easy to cross the blood-brain barrier and has a better target for cancer cells and more penetration into the tumor, leading to greater efficacy in the tumorfor treatment. Temozolamide, an effective therapeutic agent for the treatment of brain tumors, was conducted in this study. Using the ferritic nanoparticles that was loaded with Temozolamide into the encapsulated PLA (poly lactic acid), the timosulamide drug delivery with ferric nanoparticles with poly lactic acid coating has been activated with an OX26 monoclonal antibody, and with Transmission receptor targeting tumor cells(glioblastoma) used for expression of the receptor. The temozolamide test specification of nanoparticles was examined and the physiological conditions were evaluated and the extent of penetration of the drug into cancer cells was investigated. From two Glioblastomacell U215, U87 for evaluation of drug and laboratory toxicity It is used to indicate the anti-cancer activity of temozolamide and to work with monoclonal antibodies to fixed transfusion receptors, which is beneficial in increasing glioblastoma infiltration. Conclusion: Theresults of this study are a good basis for the treatment of glioblastoma tumors, which is very effective in diminishing the tumor with the use of nanosized particles of carriers of temosulamide, coated with polycarboxylic acid polymer, for targeting and penetration of the tumor.And he has a therapeutic role