A Review of the Noroprotective Effect of Medicinal Plants Against the Inflammation in The Treatment Cerebral Ischemia

Stroke as third largest the reason for long term disability and death after cancer and cardiovascular disease and the second largest cause of pat physiological damage in adult. Approximately 60% of the population who have had cerebral ischemia with some form of disability such as paralysis, loss of sensory and motor function, loss of memory, language problems, and vision problems. The use of herbs and medicinal plantsin different countries is increasing. Considering the intricate pathological process of cerebral ischemia, the use of one single agent does not seem ideal for treatment. Hence, studies in search of impressive compounds and methods are underway. Today, herbal medicine is used asalternative or complementary therapies with fewer side effects. New findings propose that some herbal medicine have the ability to aim multiple pathophysiological processes involved in cerebral ischemia including oxidative stress, inflammation, and apoptotic cell death.This study aimed to introduce the pathogenesis of cerebral ischemia and review the effects of medicinal plants and their mechanisms of action in cerebral ischemia. In this study is an overview survey about herbal medicines that evaluated in different resources andscientific databases including PubMed, ISI, Scopus, the title of herbal medicines and their keywords in treating cerebral ischemia. The review of administers studies showed that medicinal plants and their compounds are capable of diminishing infarct volume, cerebral edema, blood-brain barrier, deficit neurology through reducing oxidative stress also reducing the expression of inflammatory cytokines, microglial and astrocyte activities. Moreover, these plants are able to inhibit apoptotic protein expression and elevate anti-apoptotic protein expression. Conclusion: Therefore, Medicinal herbs and their compounds can be used as new sources against cerebral ischemia