Investigating the Potential Impact of Variables in non-Translocational Regions of Key Genes in Parkinsonʼs Disease and Their Relationship withDisease Progression

Parkinsonʼs disease (PD) is a disturbance of progressive neurodegenerative disorder in the nervous system qualified by poly faceted and variedmotor- and non-motor symptoms and possible interaction of genetic and environmental risk factor. PD is the second most commonly reported disease is the CNS. One of the possible cause is single-nucleotide polymorphisms (SNP) in the untranslated region (UTR)of active genes in CNS. The literature review was used to collecting the PD-related most susceptible genes. Then, using miRNASNP database, the miRNA-related SNPs located on the 3ʼUTR of genes were identified. Finally, the pathway enrichment analysis was performedby the KEGG database. Our results demonstrated that SNCA, LRRK2, and PINK1 are critical genes in PD progression, in which on their 3ʼUTR there are some high-frequency polymorphisms located within the miRNAs target site. These variants may result in an expression blockage of mentioned genes during PD. The pathway analysis resulted to found that miRNAs in genes (SNCA rs17016074 G/A with miRNA: hsa-miR-499a-3p, LRRK2 rs3886747 C/T with miRNA: hsamiR- 551b-5p/3p, PINK1 rs1043502 T/G with miRNA: hsa-miR-3126-5p/3p) have interfering effects on same of the cancers and hepatitis genes. Conclusion: Upon the fact that any changes in SNP alleles cause mutations inthe vital genes for the normal functioning of the nervous system, it can be stated that these SNPs may play role in development and progression of PD. These results may open the new route to develop molecular controlling of Cancer, Hepatitis and PD in future