Combining Nanotechnology and Herbal Drug Delivery in Treatment of Alzheimer’s Disease

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 345

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شناسه ملی سند علمی:

NIMED03_235

تاریخ نمایه سازی: 7 آبان 1398

چکیده مقاله:

Inflammation is implicated in the diverse neurodegenerative disorder. In Alzheimer disease (AD), beta-amyloid peptides accumulate in the brain that activates microglia, produces cytokines and causes oxidative damage. Drug that control inflammation due to lack of penetration in the blood-brain barrier (BBB), wasting drug and clinical interaction is less effective. Pharmaceutical nanotechnology means the production of pharmaceutical products with dimensions ranging from 1 to 100 nm. It is used to control drug release and increase its solubility. In this method, the plants used in the phytosome form or encapsulated forms such as a liposome. Many of the materials that come from theplants, such as flavonoids, play an important role in antiinflammatory and antioxidant activities and inhibit the activity of acetylcholinesterase enzyme which increases communication between nerve cell. If medicinal plants are used in the form of nanomedicine, they will absorb better and increase the stability of drugs and biocompatibility and reduce the dose required and side effects. These drugs improve cognitive functions such as episodic memory, language, and executive abilities. The limitation of herbal nano drugs is that quickly passes through the membrane and its toxicity is not fully understood. If their size is inappropriate, it creates problems in the capillary and renal system. Conclusion: In conclusion, because the failure of pharmacotherapy in the treatment of AD, nanotechnology should be combined with plants to reduce the adverse effects and also drug delivery to the brain will be more effective

نویسندگان

Elahe Alizadeh

Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran