The Effect of Ghrelin Intrahippocampal Injection on Motor Balance, Memory in Rat

Today, memory impairment in neurodegenerative diseases Like Alzheimer, is one of the major dilemmas. Ghrelin is a peptide hormone thatis synthesized by hypothalamus, pituitary, and some other tissues. This hormone may affect learning and especially motion memory in the hippocampus. The aim of this study was to investigate the effects of ghrelin intrahippocampal injection otor coordination, memory. Materials and Methods: 36 male rats were divided into 6 groups, including control, saline, ghrelin (0.3, 1.5 or 3 nmol) and citicoline. All groups were trained in the rotarod test for 3 times to each rat. Results: the result showed that dosage 3 nmol of ghrelin significantly can be improved motor coordination and memory in competition to citycholine (P<0.0001). Conclusion: It seems that ghrelin could be used to treat memorydisorders such as Alzheimer’s