The Protective Activity of Nanomicelle Curcumin in Bisphenol A-Induced Neurotoxicity Following Subacute Exposure in Rats

Bisphenol A (BPA), a nonsteroid endocrine-disrupting chemical (EDCs) and a xenoestrogen, is used in production of polycarbonateplastics and epoxy resins. Curcumin, a bright yellow pigment and the active component of turmeric, is a strong protective compound against brain disorders. The purpose of the study the protective property of nanomicelle curcumin on BPA induced sub-chronic neurotoxicity in rats was assessed. Materials and Methods: Rats were divided into six groups including control ,BPA 50( mg/kg ,gavage ,)nanomicelle curcumin 50( mg/kg ,gavage ,)nanomicelle curcumin (10, 25, and 50 mg/kg) along with BPA 50 mg/ kg. The treatments were continued for 4 weeks.Biochemical analysis (SOD, CAT, GST, GPx and GR), measurement of MDA concentration, and GSH content were evaluated. Results: Results displayed that BPA significantly increased malondialdehyde concentration ,SOD and GST enzymes activity and decreased glutathione content ,CAT ,GPx and GR enzymes activity in comparison with control group .However ,nanomicelle curcumin 50( mg/kg) significantly improved these toxic effects of BPA in rat cerebellum ,cortex ,and hippocampus tissues. Conclusion: The results of this study support the idea that nanomicelle curcumin exhibited preventive effects on sub-chronic exposure to BPA induced neurotoxicity in the brain tissue in rats