Evaluation of Vitamin E Effects on Behavioral, Motion and Cognitive Function in Autistic Model Rats

Previous studies have shown that autism, is a disorder of the advanced neurodegenerative group that is characterized by disturbances in social and communication relationships, often associated with repetitive and stereotypical behaviors and patterns.Some studies have suggested that vitamin E may have a beneficial effect on autism-related disorders. The aim of this study was to determine the effect of this vitamin administration on behavioral, motor and cognitive functions in autistic model rats. Materials and Methods: In this experimental study, valproic acid was injected on day 12 of pregnancy (when the embryonic development of the neural tube occurs) for induction of autism. Also, some groups were injected with Vitamin E (5 and 10 micrograms per kilogram of animal weight) or vehicle were placed intraperitoneally. On the other hand, all mice were tested on days 30 and 60 (Maze Plus, Hot plate, Rotarod, Open field, Morris Water Maze). Results: Data analysis showed that injection of valproic acid can cause behavioral disorders including decreased social interactions, increased repetitive behaviors, increased pain tolerance thresholds, increased anxiety decreased behavioral behaviors, reduced balance power and motor learning, and cognitive change in rat infants undergo postnatal evaluation, which is usually done on days 30 and 60, and the administration of Vitamin E can significantly modify these abnormalities. (P<0.05).Conclusion: These findings showed that Vitamin E can modify behavioral, motor and cognitive functions in autistic model mice and may be effective in the pharmacological treatment of autistic dysfunction