Adjusting Effects of Sodium Valproate on Hippocampal Levels of NF-KB, S100B and GFAP Following the Alloxan Induced Diabetes

Chronic diabetes with uncontrolled hyperglycemia causes neuropathy. Sodium valproate has neuroprotective and regenerative effect inneurodegenerative disease. We investigated the effectiveness of chronic valproate on diabetes induced modification in the hippocampal levels of NF-KB, AP-1, S100B and GFAP. Materials and Methods: 24 adult male C57B15/J mice were used. Diabetes was induced by alloxan (150 mg/kg; i.p.). Valproate were administrated (100 mg/kg; i.p) every 72 hours for two months. Fasting blood sugar were measured at thebeginning and at the end of experimental procedure, then animals were killed, hippocampus were extracted and prepared for ELISA to assess biochemical factors. Results: Increased blood glucose due to alloxan induced diabetes were significantly reduced following thechronic valproate administration (P<0.05). Also, chronic valproate administration in diabetic animals were significantly reduced, elevated level of hippocampal NFKB, S100B and GFAP (P<0.05).Conclusion: It seems valproate is able to adjust diabetes induced modificationin biochemical factors of the hippocampus and might be effective in diabetic neuropathy.