Effect of Vitamin E on Cisplatin-Induced Memory Impairment in Male Rats

Neurotoxicity is one of the adverse effects of cisplatin (CP) due to inflammation and oxidative stress in central nervous system. In present study we assess the protective effects of vitamin E (Vit E) on learning and memory impairments in cisplatin-induced cognitiveimpairment and hippocampus tissues oxidative damage. Materials and Methods: Methods four animal groups (n=7 for each group) were used as follows: (1) control, (2) cisplatin ( 2 mg/kg/7day , i.p), (3) cisplatin+ Vit E (200 mg/kg/7day , i.p), (4) Vit E (200 mg/kg/7day , i.p).The spatial memory was evaluated by using Morris water maze test (MWM) after one week. Hippocampus concentration of Malondialdehyde (MDA), thiol and superoxide dismutase (SOD) were measured by biochemical methods. Results: Cisplatin significantly increased the escape latency but decreased the percentage of time spent and traveled pathway in target quadrant on final trial test day (p < 0.05). Supplementation with Vit E significantly revers all results of spatial memory test (p < 0.001). Biochemical data indicated that Vit E decreased MDA but increased thiol and SOD activity (p < 0.05). Conclusion: Our findings have shown that Vit E improves cisplatin-induced memory impairmentpossibly through effect on hippocampal oxidative status.