Immune-Mediated Cerebellar Ataxias

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 374

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شناسه ملی سند علمی:

NIMED03_032

تاریخ نمایه سازی: 7 آبان 1398

چکیده مقاله:

The current article reviews the clinical presentations of immune-mediated cerebellar ataxia and analyzes the association with autoantibodies. Emerging evidence suggests that autoimmunity is involved in a significant proportion of patients presented with ataxia. Moreover,numerous autoantibodies have recently been described in association with cerebellar ataxias. The cerebellum is a vulnerable target of autoimmunity in the CNS and immune-mediated cerebellar ataxia is an important differential diagnosis in patients presenting with signsand symptoms of cerebellar disease. Immune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto’s encephalopathy among others. More than 30 different autoantibodiestargeting brain antigens have been reported in patients with Immune-mediated cerebellar ataxias, many of which are of paraneoplastic origin. Efficient biomarkers are still lacking and in many cases the diagnosis has to rely on a body of converging evidence

نویسندگان

Mehran Ghaffari

Shahid Beheshti University of Medical Sciences, Tehran, Iran