Effect of Vitamin E on Sperm Parameters and Ex-pression of ODF Gene in Infected Mice with Chlamydia Trachomatis

Background: Some bacteria example Chlamydia Trachomatis is the most prevalent bacterial cause of sexually transmitted infec-tions in the world and can result in severe genital disease. Over 90 million chlamydial infections are detected annually world-wide and various studies have estimated that there are four to five million new cases of chlamydial infection each year in the USA. The aim of this study was to investigate the harmful effects of Effect of vitamin E on sperm parameters and Expression of ODF gene in infected mice with Chlamydia Trachomatis.Materials and Methods: 24 Adult rats were divided into four groups: control, infected with C. Trachomatis, infected with C. Trachomatis + Vitamin E, Vitamin E (100mg/kg/day). Treat-ments were performed till 4weeks. Left caudal epididymis was cut in Ham s F10. Released spermatozoa were used to analyze number, motility and viability of the sperm also the expression of ODF gen was analyzed by real-time PCR.Results: In present study our results showed treatment of ani-mals with C. Trachomatis significantly decreased of Motility, number, viability, sperm tail length and daily sperm produc-tion (P<0.001) and ODF gene expression compared to the con-trol group. While C. Trachomatis +Vitamin E group showed a highly significant increase in sperm parameters and ODF gene expression.Conclusion: Vitamin E could compensate the adverse effects of C. Trachomatis on sperm parameters in adult mices.

کلیدواژه ها:

Adult Mice ، Sperm Parameters ، Vitamin E ، C. Tra-chomatis