The Effect of Pentoxiphyline on Sperm Parameters and Biochemical Factors in Mouse Treated with Dexameth-asone

Background: Infertility in menʼs crowd is increasing and use a series of medications such as dexamethasone is one of the main reasons for infertility. Pentoxiphyline as a potent antioxidant is able to reduce oxidative stress and the harmful effects of dexa-methasone. The aim of this study was to evaluate the preventing effect of Pentoxiphyline on sperm parameters and biochemical factors in in Mouse Treated With Dexamethasone.Materials and Methods: This study 24 Adult male NMRI mice (35±2 gr.) were divide randomly into 4 groups (n=6): control, Dexamethasone (7mg/kg/day), pentoxiphyline (200mg/kg/day), Dexamethasone + pentoxyphiline. After 7 days of treatment, the left caudal epididymis was cut in the Ham s F10 and the released spermatozoa were used to analyze sperm parameters, biochemi-cal factors and daily sperm production were also measured. Data were analyzed using one way ANOVA and Tukey’s test and the means were considered significantly different at P<0.05.Results: Motility, number, viability, sperm tail length and daily sperm production (P<0.001), Serum testosterone level (P<0.001), TAC (P<0.001) while in the volume of interstitial tissue and MDA level significantly increased in the Dexametha-sone group when compared to the control. Co-administration of Dexamethasone and pentoxiphyline didn’t significantly com-pared to control group on the above parameters Co-administra-tion of Dexamethasone and pentoxiphyline didn’t significantly compared to control group on the above parameters (P> 0/05). Conclusion: This study showed that simultaneous treatment of pentoxiphyline and dexamethasone can prevent the adverse effects of on sperm parameters, biochemical factors and daily sperm production.

کلیدواژه ها:

Pentoxiphyline ، Sperm Parameters ، Dexamethasone ، Biochemical Factors ، Mice