Intracytoplasmic Sperm Injection Versus Convention-al IVF for Treatment of Non-Male Factor Infertility.

Intracytoplasmic sperm injection (ICSI) was first introduced by Palermo in 1992.At that time, the indication of this method was to help men with severe semen parameters abnormality, including oligoastheno-spermia.In the severe sperm abnormalities, ICSI was able to achieve fertilization rates equal to those with normal semen parameters. During the last two decade ICSI has been gradually expanded to treat moderate semen abnormality or even couples with non-male infertility.The strong evidences from USA national data showed that in non-male factor infertility treatment, ICSI use was not asso-ciated with higher rate of implantation rate compared to con-ventional IVF (23% Vs. 25.5% respectively) and live birth rate(36.5% versus 39.2%),respectively.ICSI procedure is and invasive method. This procedure pre-vents the natural selection barrier of oocyte. Bypassing the se-lection barrier of oocytes may result in many genetic abnormal-ity of the resulting embryo.In this lecture we will try to compare the effectiveness of ICSI and IVF in patients with non-male factor infertility.