Gold Nanoparticles: Synthesis and Application in Drug Delivery

Inorganic nanoparticles and their combination with organic materials forming hybrid materialspossess unique physical, chemical, optical and electrical properties which make them differentand more applicable than large size materials. These types of platforms can be synthesizedby different organic, inorganic or hybrid of organic and inorganic materials but amongall these inorganic platforms are of most important for diagnosis and simultaneous therapydue to their easy modification, stability and high drug loading capacity [1]. Metal nanoparticlesspecifically gold nanoparticles have abundant use in the field of biotechnology and biomedicinebecause they have large surface bio conjugation with molecular probes [2]. In thisstudy, we synthesized Au-peptide nanoparticles using organic reducing agents under microwaveand ultrasound irradiation, and then, their anticancer effects were investigated. The resultingAu-nanoparticles were characterized using different techniques such as UV-Vis spectroscopy,Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy,and transmission electron microscopy. The interaction of calf thymus DNA withAu-nanoparticles was studied by UV-Vis spectrophotometry at 300 and 310 K. [L]1/2, ΔG0,ΔS0, and ΔH0 values at 300 K were found to be 0.24352 mM, 26.729 (KJ/mol), 0.8574(KJ/mol.k), and 286.435 (KJ/mol), and at 310 K, 0.33248 mM, 19.17 (KJ/mol), 0.8587(KJ/mol), and 286.435 (KJ/mol), respectively. Kapp, n and g values were obtained 83.24,6.74 and 4 at 310 K, respectively.