Fabrication and Study of Nigella sativa-Loaded Electrospun Nanofiber

In this study, Zein and Nigella sativa solution was prepared with three different Nigella sativaconcentrations of 5, 10, and 15 %w/v, and was electrospun. The voltage of electrospinningprocess at these three concentrations being 20kv; the distance between the tip of the needleand the collector in the three concentrations being 15cm; and the flow rate at the three levelsbeing 4ml/h, were all constant. Results showed that changes in the concentration of Nigellasativa oil have a significant effect (? ≤ 0.05) on fibre diametre; increasing the concentration ofthe Nigella sativa oil results into the increase of fibre diametre. Recently, biodegradable polymershave been widely used as drug carriers in the human body [1, 2]. These polymers havebeen used because they have very low, and near-to-zero, effects on human body; and one oftheir most important characteristics is that they are suitable carriers for drug delivery, andhave direct response to physiological stimuli; and they are also non-official and economical[1, 3]. The purpose of this study is to produce microfibre of Zein protein and Nigella sativa oilwith glacial acetic acid solvent. It will also investigate the effect of changing Nigella sativa oilconcentration on the morphology and diametre of fibres.