PTSA: A FacileCatalyst a One-Pot Synthesis of 2-Arylpyrrolo[2,3,4-kl]- 1(2H)-one under Mild Conditions
محل انتشار: بیست و ششمین سمینار شیمی آلی ایران
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 289
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شناسه ملی سند علمی:
ISOC26_166
تاریخ نمایه سازی: 2 شهریور 1398
چکیده مقاله:
Synthesis of heterocycles has always been a topic of great interest owing to the agricultural,pharmacological, and industrial significance of the majority of heterocyclic structures [1].Among an immense variety of N-heterocyclic compounds, acridine moieties are preeminentdue to their multiple pharmacological and biological activities [2]. Many procedures havebeen extended for synthesis of these scaffolds via hantzch reaction. However, a vast survey ofthe literature disclosed that there are a few synthetic methods for construction of pyrroloacridineswith three-component reaction of dimedone, various anilines, and isatin [3]. Hence, wedeveloped the synthesis of medicinally important 2-arylpyrrolo[2,3,4-kl]acridin-1(2H)-onesby an efficient and convenient approach of three-component reactions of dimedone, variousanilines, and isatin in the presence of PTSA as environmentally benign and effective catalyst.This work presented here has the merits of environmental friendliness, easy operation, simplework-up, excellent yields. Chemical structures of all molecules were characterized by spectraldata and elemental analysis.
نویسندگان
Mahdieh Sanclooli
Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box ۹۸۱۳۵-۶۷۴,Zahedan, Iran
Nourallah Hazeri
Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box ۹۸۱۳۵-۶۷۴,Zahedan, Iran
Maryam Kochakzay
Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box ۹۸۱۳۵-۶۷۴,Zahedan, Iran
Maryam Shokoohian
Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box ۹۸۱۳۵-۶۷۴, Zahedan, Iran