Peripheral nerve regeneration using electeroconductive scaffolds

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 451

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شناسه ملی سند علمی:

ITERMED01_272

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

IntroductionPeripheral nerve injury is a common clinical problem that followed by Wallerian degeneration, axonal sprouting, and remyelination. Autologous nerve grafts that are as the gold standard of therapeutic strategies, in spite of several advantages, show several limitations including of limited availability, donor site morbidity, the formation of neuroma and infection. Therefore, today many efforts are being made to design and construct artificial nerve grafts that act analogous to the natural extracellular matrix and can guide the axonal outgrowth. The chemical and electrical cues of the extracellular matrix provide an ideal environment to the adhesion and proliferation of neural cells and the presence of these cues in scaffolds play an important role in regeneration. Electrical stimulation (ES) conductive scaffolds have been shown to promote remyelination and axonal regeneration. ObjectivesIn this paper, the first is reviewed electrical properties of nerve cells and the effects of electrical stimulation on theirs. Then, utilized electrically conductive polymers for nerve tissue engineering and also suitable scaffolds for peripheral nerve regeneration are discussed. Conclusion Although an electrical environment created by ES within the conductive scaffolds improves nerve regeneration and functional recovery, the more clinical studies are needed

نویسندگان

Maedeh Entezari

Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Mansoureh Soleimani

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

Masoud Mozafari

Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran

Mehrdad Bakhtiyari

Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran