The bench of acellular matrices and its application for the tissue engineering

Tissue-engineering approaches have made considerable advances over recent years and it is likely that this application will realize clinical success in the near future. Conventional tissue-engineering scaffolds based on biodegradable polymers or collagen may not be suitable in some situation because of their initial limited strength. Recently novel methods have been created optimal decellularization technique that removes the cells without damaging the matrix of tissue. In this way, this article reviews the concepts involved acellular matrices and its application as novel suitable scaffolds in tissue engineering applications. We carried out this systematic review of literature with acellular matrices related keywords in PubMed, Google scholar and Scopus, published since 2000 to now and summarized here. Acellular matrices derived from natural tissue are gaining increasing attention for their role in tissue engineering and regenerative medicine applications. Acellular matrix is obtained by removing cellular components from donor organs, leaving a tissue matrix consisting of collagen, elastin, fibronectin, glycosaminoglycans, proteoglycans, and growth factors. Unlike conventional scaffolds based on biodegradable polymers or gels, acellular matrix posses native biomechanical and many acquired biologic properties. A number of acellular scaffolds have already been tested clinically unseeded with cells and suggest that tissue engineering techniques may provide efficacious alternatives to current methods of tissue regeneration. Over the last few decades, both synthetic and natural materials have been utilized to develop tissue substitutes for tissue replacement therapies. Most attempts have not been successful because of mechanical, structural, functional, or biocompatibility limitations of some scaffolds, so acellular matrices-based scaffolds are ongoing and would be greatly assisted by a noninvasive means to characterize scaffold properties and monitor interaction with cells; the gist it seems that acellular matrices could be more suitable agents in tissue engineering

کلیدواژه ها:

Tissue engineering ، Acellular matrices ، Scaffolds