How the compliance behavior of nanofibrous tubular scaffold as an artificial common bile duct changes with electrospinning parameters

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 351

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شناسه ملی سند علمی:

ITERMED01_118

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

The common bile duct is a tube connecting the liver to the small intestine. In this study, an artificial tube made up of electrospun medical grade polyurethane nanofibers was used as a biomedical structure for the common bile duct. The compliance is one of the most important mechanical properties of tubular prosthetic, which should be adequately compliant, as long as possible, to keep the behavioral integrity of prosthetic. The compliance behavior of electrospun polyurethane tubes was investigated, as the response of the main electrospinning parameters, including polymer concentration, applied voltage, tip to collector distance and feed rate to optimize this biomechanical property of electrospun tubes. The empirical modeling, based on response surface methodology (RSM) analysis, confirmed that the compliance was enhanced by increasing electrospinning distance and feed rate, while applied voltage had the decreasing effect on compliance. Our findings show that the studied parameters affected the compliance of electrospun tube by changing wall thickness of tubular scaffolds. The RSM model also predicted the compliance value of native common bile duct, which is equal to 1.6 at conditions of the polymer concentration of 8.2 w/v%, the applied voltage of 19 kV, the tip to collector distance of 15 cm, and the feed rate of 0.375 ml/h. The experimental compliance measured at the optimum conditions was obtained 1.87, which is only 17% greater than the predicted value of 1.6. This indicates that the compliance property of tubular nanofibrous scaffolds can be close to ideal compliance by optimizing of electrospinning parameters.

کلیدواژه ها:

Compliance ، Medical grade polyurethane nanofibers ، Electrospinning ، Optimizing

نویسندگان

Mehdi Sadrjahani

Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran.

Najmeh Moazeni

Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran.

Masoud Latifi

Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran.

Dariush Semnani

Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran.