Effect of malva neglecta wallr on renal tissue

Introduction Nephrolithiasis is a worldwide problem. Despite many methods for nephrolithiasis treatment, there is still no satisfactory drug to prevent and treat renal stone. Malva neglecta Wallr (Malva.N) commonly known as panirak is used in folk medicine for nephrolithiasis ObjectivesThe aim of this study is to investigate the effects of Malva neglecta Wallr on renal tissue and kidney calculi in rat model. MethodsSixty- four male Wistar rats were randomly divided into 8 groups (n=8): Normal control (Group I), Disease control (Ethylene glycol, EG, Ammonium chloride, AC, Group II), Sham (Groups III& IV), preventive (Groups V & VI) and curative (Groups VII& VIII). Group I, received tap drinking water, Groups III, IV were given intra- peritoneal injections of 200& 800mg/kg extracts for 28 days. Groups II, V, VI, VII and VIII received EG 1% +AC 0.25% in drinking water for 28 days. Groups V & VI received intra- peritoneal injections of 200& 800mg/kg extracts for 28 days and Groups VII& VIII were given intra-peritoneal injections of 200& 800mg/kg extracts from the 14th day of the experiment. At the end of experiment kidneys were removed and examined for tubulointerstitial changes and CaOx deposits. ResultsThe aqueous extract of Malva.N significantly decreased tubulointerstitial damage and CaOx deposits in the preventive groups (P < .001). In curative groups, a low dosage of aqueous extract reduced tubulointerstitial damage (P = .023) and kidney oxalate deposits (P = .033). In addition, a significant decrease was observed in tubulointerstitial damage and crystal deposition in high dosed group (P < .001). ConclusionAccording to these results, Malva.N has beneficial effects on preventing and treating CaOx deposition and decreasing the tubulointerstitial damage. These effects may be due to component presented in this plant such as mucilage, saponins, flavonids, and phenolic compounds

کلیدواژه ها:

Ethylene glycol ، Ammonium chloride ، Malva neglecta Wallr ، Renal tissue ، Kidney calculi