Design, fabrication and evaluation of chitosan and gelatin nanofibers for tissue engineering applications

ObjectivesIn this study, nanofibers were electrospun from chitosan and gelatin at several blends (chitosan/gelatin: 80/20, 60/40, 50/50, 40/60, 20/80) with different processing parameters (voltage, flow rate and distance between the tip of the needle and collector).MethodsFourier transform infrared (FTIR), scanning electron microscopy (SEM), in vitro degradation and tensile test were utilized to evaluate the scaffolds for biomedical applications. The samples with 20% chitosan and 80% gelatin under special processing conditions (flow rate: 0.1 mL/h, voltage: 12 kV and distance: 16 cm) had the least amount of droplets and beads.ResultsTensile mechanical test showed that the crosslinked nanofiber scaffold with 20% chitosan and 80% gelatin is the best choice when mechanical properties are required. In addition, the crosslinked scaffolds with 20% chitosan and 80% gelatin and 50% chitosan and 50% gelatin had the least and most amount of degradation respectively

کلیدواژه ها:

Nanomaterials ، Electrospinning ، Tissue engineering ، Chitosan ، Gelatin