Clincopathological characteristics and prognostic factors of colorectal cancer patients, Yazd, Iran

TITLE: Clincopathological characteristics and prognostic factors of colorectal cancer patients, Yazd, Iran Shokouh Taghipour zahir1, Seyed Zakarya Mousavi nasab2, Danial Chaleshi31. Department of clinical and surgical pathology, shahid sadoughi university of medical sciences, Yazd, Iran2. Emergency resident, Esfahan university of medical sciences, Esfahan, Iran 3. Students research committee, shahid sadoughi university of medical science, Yazd, IranIntroductionColorectal malignancies are the most prevalent gastrointestinal cancers. Considering the high prevalence and the possibility of relapse due to the type of surgical procedure and treatment, we determined to study the prognostic factors and overall survival rate according to the type of surgery and treatment in years between 1382 to 1392.Material and methods This descriptive study was conducted on 275 patients (169 males and 106 females). The data collecting was performed by referring to the YAZD hospitals records of the patients and filling out the checklists according to the relapse and survival rate. Collected data were analyzed in SPSS software (version 17). P value less than 0.05 considered statistically meaningful. Results:Average survival in men and women were 64.61+-2.23 and 75.41+3.17 months respectively. It was no statistically meaningful correlation between tumor grade, age and sex of patients with survival time (p value: 0.59) (p value: 0.40) (p value: 0.37) respectively. However, there was statistical relation between time of survival with stage, anatomical location of tumor and type of treatment (p value: 0.00) (p value: 0.01) (p value: 0.01) respectively. Patients whom underwent neo-adjuvant therapy had a shorter survival compared with those underwent adjuvant therapy. Poorly differentiated tumors had a shorter survival time, but it was not statistically significant. There was no statistically significant correlation between variables and recurrence rate (p value> 0.05). Discussion In the various types of colorectal tumors, overall survival time was longer in patients with descending colon and sigmoid tumors than in transverse colon tumors. The time of Survival was better in patients who had received surgical operation at the first in comparison of whom underwent neo-adjuvant therapy prior to surgery. Also survival time in patients with the lower stages was better than advance stage. Tumor location and type of therapy were effortless in relapse.

کلیدواژه ها:

Colorectal ، sigmoid ، survival ، relapse ، YAZD