To survey the effects of selenium supplementation on glucose homeostasis in women with GDM referred to Hafez and Zeinabieh hospital between Azar 1394 and Esfand 1395

There are less evidences about the anti-diabetic effect of selenium supplementation in women with GDM, so our study was designed with the aim of investigating the effect of selenium supplementation on glucose homeostasis in women with GDM. Materials and Methods: The present study was designed as a prospective randomized, double blind Placebo-controlled, clinical trial which was performed on 60 pregnant women with GDM who were referred to outpatients clinic of Hafez and Zeinabieh hospitals (Shiraz, Iran) during 16 months’ period from Azar 1394 and Efanad 1395. Women were randomly assigned to take either 100 μg selenium supplements as tablet or placebo daily for 12 weeks since 24 to 28 week of gestation. The primary outcomes were the glucose homeostasis changes including fasting plasma glucose (FPG), 2HPP, serum insulin level, HbA1C, HOMA-IR at initial and 3 months after intervention. Results: The mean maternal age of the patients consumed selenium was found to be 29.19±6.16 (range 18–41) years. In placebo group, the mean maternal age of the patients was 31±4.43 (range 24–39) years. Compared with the placebo group, FPG, 2HPP, HbA1C, serum insulin, and HOMA-IR were not significantly changed in the selenium group at the end of study (P=0.25, P=0.87, P=0.34, P=0.57, and P=0.31, respectively) Conclusion: In conclusion, the findings of our trial indicated that 100 μg maternal selenium supplementation during pregnancy is safe, but it has not positive role in controlling glucose homeostasis in women with GDM.

کلیدواژه ها:

Gestational diabetes ، selenium ، glucose homeostasis