Synthetic zeolites for drug delivery

Ibuprofen was encapsulated into synthetic zeolites by a soaking procedure. Drug-loaded matrices were then characterized for entrapped drug amount. The total amount of ibuprofen (800 mg) was encapsulated in 2 g of matrix. By using UV-Visible spectrophotometeric measurements, ibuprofen release studies were done at different pH conditions so as to mimick gastrointestinal fluids. The absence of release in acid conditions and a double phased release, at two different pH values (5 and 6.8), suggest that after activation these materials offer good potential for a modified release delivery system of Ibuprofen.

کلیدواژه ها:

zeolites ، ibuprofen ، drug delivery