Minerals and Rare Elements in Patients with Breast Cancer: Review of Evidence

Introduction & Aim: Breast cancer is the most common type of cancer in women. At the onsetof the development of breast tumors, a combination of internal and external factors is involved,including rare elements. The aim of this study was to determine the level of minerals and rareelements in patients with breast cancer.Methods: This systematic review took place by searching the databases Magiran, SID, Googlescholar, Pubmed, Amedeo and elmnet with keywords Breast cancer, minerals, selenium, zinc,copper, folate and vitamin D during 2000 to 2018. In this study, descriptive, analytical and casecontrolarticles have been used.Results: The results of various studies showed that there was a significant difference betweenthe mean of copper, selenium, folate and vitamin D in the group of patients with breast cancerand control subjects. Also, with these age groups, these minerals increased in these patients.There was a controversy between the mean on the patients and the control group. In thesestudies, generally, as a case control, a healthy group was also evaluated. The concentration ofthese minerals was measured using optical methods.Conclusions: Based on the results, it can be suggested that changes in trace elements in serumlevels in breast cancer patients are a prognosis for diagnosis and treatment of this disease.Further studies on these elements and other important elements such as iron are also proposed.

کلیدواژه ها:

Breast cancer ، minerals ، selenium ، zinc ، copper ، folate ، vitamin D