Quercus Brantii Lindl. Vaginal Douch Versus Clotrimazole on Vaginal Candidiasis

Background: Vaginal Candidiasis with an approximate prevalence of 30% is the second most common cause of vaginitis worldwide, after the bacterial infection. The risk of vaginal candidiasis for non-pregnant women is approximately 20%, but it increases by 30% during pregnancy but according to a study, the prevalence of vaginal candidiasis in Iran is between 25% and 45%. Antifungal azole is the first treatment for Vaginal Candidiasis; however, some side effects have been reported for this chemical medicine. Based on the antifungal activity of Inner Stratum of Quercus Brantii (Q. Brantii), the aim of our study was to compare the effects of vaginal douche of Q. Brantii extract and clotrimazole on vaginal candidiasis symptoms before and after the treatments, in women. Methods: 89 non-pregnant women with positive KOH test which is capable of identifying the presence of hyphae and mycelium by adding KOH (10%), and a positive vaginal candidiasis culture were randomly divided into two experimental groups,using permuted block randomization method. One group received clotrimazole vaginal cream (1%) and the other group received vaginal douche of Q. Brantii extract. Groups were treated for 7 days and KOH tests and cultures were evaluated again. The data of the samples were described,using descriptive statistics, which was presented as the mean ± SD for continuous and numbers (%) for categorical data. P<0.05 was considered to indicate significant differences between the treatments. Data were analyzed via chi-square and independent t-test, using SPSS software. Results: According to the data, there were no significant differences between experimental groups for demographiccharacteristics like age (p=0.403), BMI (p=0.911), educational levels (p=0.862) and contraceptive methods (p=0.702). Moreover, no significant differences were discovered between the patients’ vaginal discharge of the two groups before the treatments (P> 0.999). However, vaginal discharge was significantly decreased in the group treated with vaginal douche of Q. Brantii compared to the group treated with clotrimazole vaginal cream after the treatment (P=0.043). Conclusion: The results suggested that the therapeutic effect of vaginal douche of Q. Brantii extract was approximately similar to that of clotrimazole vaginal cream

کلیدواژه ها:

clotrimazole vaginal cream ، extract ، Quercus Brantii Lindl. ، Vaginal Candidiasis ، vaginal douche