The association between Angiopoietin-like protein 8 (ANGPTL8) and lipid profile in type 2 diabetic patients

Background: Angiopoietin-like protein 8 (ANGPTL8) is a newly characterized circulating hormone that is produced in tissues such as adipose tissue and liver and stimulates pancreatic beta-cell proliferation. The purpose of the current study was to examine circulating ANGPTL8 levels in Iranian patients with type 2 diabetes mellitus (T2DM) and in normal controls. Methods: Seventy-five subjects were enrolled in this case-control study in the following two groups: T2DM patients (n=40) and a group of age-, sex-, and BMI-matched normal control subjects (n=35). Circulating ANGPTL8 concentrations as well as the blood lipid profile, body mass index(BMI), fasting blood sugar (FBS), glycated hemoglobin (HbA1c), and insulin resistance were determined. Results: Circulating ANGPTL8 levels were significantly higher in patients with T2DM than in the normal subjects (4.79±1.53 ng/mL vs. 2.79±1.11 ng/mL respectively; p=0.001). Serum triacylglycerol and total cholesterol were also significantly higher in patients with T2DM than in the control group. In the patients with T2DM, serum ANGPTL8 was positively correlated with age, FBS, TG, total cholesterol, and HbA1c. Conclusion: The results of this initial study in Iran have shown that circulating ANGPTL8Levels are significantly increased in Iranian patients with T2DM compared with a control group. Additionally, it is postulated that ANGPTL8 as a novel hormone may be involved in the generation of an atherogenic lipid profile.

کلیدواژه ها:

ANGPTL8 ، Type 2 diabetes mellitus ، Lipid profile