Hydroxy ethyl methyl morpholinium azide [HEMMorph][N3] as a novel and highly efficient ionic liquid for three components Click Huisgen cycloaddition reaction.

1,2,3-Triazoles are a significant group of azole derivatives with certain pharmaceutical properties. 1,2,3-Triazoles have indeed shown interesting biological activities, for instance, anti-allergic, anti-bacterial, anti-HIV and etc. 1,3-dipolar cycloaddition reaction between alkynes and azids was conducted by Huisgen cycloaddition reaction, which traditionally requires harsh reaction conditions like high temperature, non-regioselectivity and also long reaction times. The use of cupper (I) catalysts extensively accelerate the reaction’s rate up to 107, which is known as Click cycloaddition reaction [1]. The elaboration of organic solvents can remarkably damage the environment. In this regard to eliminate these hazardous materials, ionic liquids (ILs) are suggested to be utilized as environmental benign solvents.The molecular structures of ILs can be consisted or modified by diverse anions and cations. ILs are usually known as liquid compounds or can be liquefied below 100 C, and capable to be recycled and reused [2].To exploit the benefits of ILs in organic synthesis, hereby we have explained the synthesis of novel hydroxyethyl methyl morpholonium azide [HEMMorph][N3] as a highly efficient ionic liquid media and apply it in synthesis of new 1,2,3-triazolyl derivatives via three components Click Huisgen cycloaddition reaction.