Metal modified beta-cyclodextrin (MMC) exhibits high reactivity for synthesis of fused pyrimidines

In one hand, Cyclodextrins, particularly beta ones, are broadly used in the pharmaceutical field for their ability to increase the solubility and the stability of drugs and small organic molecules by the complex formation at the reaction [1]. Chemistry of Cyclodextrin is quickly becoming one of the major fields of supramolecular chemistry and catalyst. On the other hand, benzo- and hetero-fused pyrimidines are famous because of their interesting properties such as antiviral, antibacterial, anti- AIDS, and antinociceptive activities and there are some methods for preparation of this kind of compounds. However, most of the described methods suffer from disadvantages like long reaction times, poor yields, harsh conditions, the use of expensive reagents, the use of multi-step and cumbersome procedures, and no agreement with the green chemistry protocols. Therefore, development of an efficient, one-step and environmentally procedure for the preparation of fused pyrimidines is desirable [2]. Considering the above facts, in continuation of our investigations on the application of cyclodextrins in organic transformations, we design a novel cyclodextrin catalyst and report a highly efficient and simple method for the synthesis of fused pyrimidines under solvent-free condition