Synthesis of 2,3‑dihydroquinazolin‑4(1H)‑ones catalyzed by Fe3O4@nano-cellulose/CuCl2 as a bio‑based magnetic catalyst

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 277

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شناسه ملی سند علمی:

IRANCC20_422

تاریخ نمایه سازی: 28 اردیبهشت 1398

چکیده مقاله:

Recently biopolymers such as cellulose and starch [1-2] have been used as support for heterogeneous catalytic systems. In this context, cellulose can play a major roleas a natural, biocompatible and biodegradable polymer containing free OH groups with nucleophilic character for bonding to Lewis acids. Nano-cellulose was prepared via partial hydrolysis of cellulose in cotton. Fe3O4@nano-cellulose can be obtained from reaction of FeCl2 and FeCl3 via NH4OH in an aqueous solution of nano-cellulose in a simple procedure. Lewis acids such as CuCl2 can be bound to surface OH groups in nano-cellulose for preparation of Fe3O4@nano-cellulose/CuCl2 as a new, green, bio-based and recyclable magnetic nano catalyst. This catalyst was characterized by FT-IR, FESEM, TEM, XRF, VSM, EDX and XRD. 2,3- Dihydroquinazolin-4(1H)- ones are an important class of fused heterocyclic compounds which have drawn much attention because of their biological potential and pharmaceutical activities such as anti- inflammatory, antibacterial, antitumor, antimicrobial and antioxidant [3]. In this report, 2,3-dihydroquinazolin-4(1H)- ones can be synthesized via condensation of 2-aminobenzamide and aldehyde in the presence of Fe3O4@nano-cellulose/CuCl2 in water at room temperature (Scheme 1). This protocol includes some important advantages such as short reaction times, high yields, simple methodology and easy work-up. The nano-catalyst could be recycled and reused without significant loss of its catalytic activity

نویسندگان

Bi Bi fatemeh mirjalili

Department of Chemistry, Faculty of Science, yazd University, yazd, Iran

nasrin safajoo

Department of Chemistry, Faculty of Science, yazd University, yazd, Iran

abdolhamid bamoniri

Department of Chemistry, Faculty of Science, University of kashan, kashan, Iran