Fabrication and characterization of polyaniline nanotubes/silver composite for the electrochemical sensing of anticancer drug,5- Fluorouracil

A polyaniline nanotubes/silver composite (PANINTs@AgNPs) was prepared through a simple one-step method without using any extra acid, reducing agent, and template [1]. The as−prepared nanocomposite characterized by Field Emission Scanning Electron Microscopy (FESEM), size distribution diagrams and X−ray diffraction. The resultant nanocomposite not only possessed high specific surface area but also exhibited good stability and durability. The study was explored using the Taguchi experimental design method and the results were confirmed by the ANOVA [2]. We weigh 0.002 mg of the silver-polyaniline nanotube composite added with HCl (10 ml). The solution was sonicated for 10 min to achieve homogeneous suspension. We select the potential range of (-0.2 to 0.10 V), and the number of cycles of 20. The nanoscale is reduced by the electrode surface. The designed sensor could detect 5- Fluorouracil (5-FU) in the dynamic linear range from 20 μM to 380 μM, with a low detection limit of 0.06 μM (S/N=3). Additionally, the fabricated sensor showed excellent selectivity and acceptable sensitivity. The satisfactory results in analysis of human serum samples indicated that it had potential application in clinical monitoring of 5-FU.

کلیدواژه ها:

Polyaniline Nanotube ، Silver nanoparticles ، 5- Fluorouracil ، Sensor