Copper oxide supported on magnetic nanoparticles (CuO@γ-Fe2O3) for addition of amines to carbodiimides toward synthesis of guanidines

In this study, copper oxide supported on magnetic nanoparticle was used as an green magnetic nanocatalyst for hydroamination of carbodiimides towards synthesis of guanidines. Easy preparation and separation, Low price, non sensitive to moisture, and reusability of catalyst along with diversity and high yield of the products are silient features of this method. Recently, we have reported the preparation, characterization, and catalytic evaluation of maghemite supported copper oxide nanocatalyst for the N–H insertion reaction with ethyl diazoacetate. Continuing our works in designing and using magnetic heterogeneous catalysts, herein we have tried to use this magnetic nanocatalyst for addition of amines to carbodiimides toward synthesis of substituted guanidines. Facile preparation of catalytic system from the low cost starting materials, easy separation from the reaction mixture, by using an external magnet, with the ability to re-use and recycling as well as the synthesis of various guanidines under mildreaction conditions are silient features of this procedure