Synthesis of quinazolines over recyclable Fe3O4@SiO2-APTES-Fe3+ nanoparticles: A green, efficient, and solvent-free protocol

One of the most important nitrogen heterocycles found in a wide variety of natural products is quinazoline. It has received great attentions in organic synthesis and medicinal chemistry [1,2]. A practical and efficient method is developed for efficient synthesis of quinazoline derivatives through condensation reaction of 2- aminobenzophenone, an aldehyde, and ammonium acetate [3], over magnetic Fe3O4@SiO2-APTES-Fe3+ NPs as a recyclable nanocatalyst, under solvent-free conditions. The as-prepared nanocatalyst is characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), thermogravimetry analysis (TGA), and vibrating sample magnetometer (VSM). The advantages of this protocol includes, avoiding the use of solvent, easy handling, short reaction time, simple experimental, product purity, and nontoxicity, economical and environmental friendly nature of the iron catalyst are the attractive features of this methodology. These together with the simple recovering of catalyst makes it a useful alternative for the scale-up for the synthesis of quinazoline derivatives [4,5].