Efficiet one-pot synthesis of pyrazoles catalyzed by Nano silica sulfamic acid, Graphene oxide and Cobalt titanate(III) using green chemistry

Pyrazole derivatives have become increasingly important in the past few years because they have proven to be extremely useful intermediate for the preparation of new biological materials. The pyrazole ring is present in numerous pharmacological compounds [1-4]. Pyrazoles are an important structural subunit found in a variety of biologically active agents, including major drugs such as Viagra, Xalkori, Lexiscan, and Celebrex. The prevalence of the pyrazole motif in medicinally relevant compounds, dyes, and ligands for metal catalysts has inspired the development of many novel methods for their preparation. Many procedures for the synthesis of pyrazoles derivatives have been developed during the last two decades. But the most efficient method of choice is the reaction of 1,3-diketones with hydrazines and their derivatives. For the synthesis of pyrazole reactions between 1,3-diketones and hydrazines with catalyst Nano silica sulfamic acid, Graphene oxide and Cobalt titanate(III) solvent-free condition using green chemistry have been reported.Obtaining the product in the short reaction time and good to excellent yields, using catalytic amount of catalyst, easy work up and avoidance of using solvent are notable advantages of this method. The experiments a number of substituted Pyrazole derivatives is prepared by melting point and spectroscopic techniques, have been identified