An efficient three-component synthesis of triazolo[2,1‑b]quinazolinone derivatives catalyzed by reusable DABCO‑based dicathionic ionic liquid

Various biological and pharmacological properties of triazolo[2,1-b] quinazolinones derivatives have attracted wide interest for the preparation of these compounds. Fluconazole, itraconazole, and albaconazole are some examples antifungal drugs which possess triazole moiety in their structures. [1] In recent years, Ionic liquids have been utilized as alternatives to hazardous, volatile and flammable solvents and catalysts, and due to their distinctive physicochemical properties such as polarity, solvating activity, melting point, density, and viscosity. Furthermore, dicationic ionic liquids are attractive new category of ionic liquids that represent higher melting point, wider liquid range and better thermal stability in comparison with traditional ionic liquids. [2,3] In this study, a convenient and straightforward method for the synthesis of triazolo- [2,1‑b]quinazolinone derivatives, through a three-component reaction between aldehydes, β-diketones and 3-amino-1,2,4-triazole in the presence of an economical and reusable DABCO‑based dicathionic ionic liquid has been reported (Fig. 1). The advantages of present methodology are ease of the preparation and handling of the catalysts, simple procedure, acceptable reaction times, non‑column chromatographic separation, high yields, and recyclability of the catalyst.